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Article

Examining the effect of linkage disequilibrium on multipoint linkage analysis.

BMC genetics - 30 Dec 2005

Huang Qiqing, Shete Sanjay, Swartz Michael, Amos Christopher I

Abstract excerpt

Most linkage programs assume linkage equilibrium among multiple linked markers. This assumption may lead to bias for tightly linked markers where strong linkage disequilibrium (LD) exists. We used simulated data from Genetic Analysis Workshop 14 to examine the possible effect of LD on multipoint linkage analysis. Single-nucleotide polymorphism packets from a non-disease-related region that was generated with LD...

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Identifiers

PMID: 16451698
DOI: 10.1186/1471-2156-6-S1-S83
PMCID: PMC1866697

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