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Article

The Maximum-Likelihood-Binomial method revisited: a robust approach for model-free linkage analysis of quantitative traits in large sibships.

Genetic epidemiology - 1 Jan 2011

Cobat Aurelie, Abel Laurent, Alcaïs Alexandre

Abstract excerpt

Model-free linkage analysis methods, based on identity-by-descent allele sharing, are commonly used for complex trait analysis. The Maximum-Likelihood-Binomial (MLB) approach, which is based on the hypothesis that parental alleles are binomially distributed among affected sibs, is particularly popular. An extension of this method to quantitative traits (QT) has been proposed (MLB-QTL), based on the introduction...

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Identifiers

PMID: 21181896
DOI: 10.1002/gepi.20548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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