Incorporation of covariates in multipoint model-free linkage analysis of binary traits: how important are unaffecteds?

doi:10.1038/sj.ejhg.5200682

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Article

Incorporation of covariates in multipoint model-free linkage analysis of binary traits: how important are unaffecteds?

European journal of human genetics : EJHG - 1 Aug 2001

Alcaïs A, Abel L

Abstract excerpt

When the mode of inheritance is unknown, genetic linkage analysis of binary trait is commonly performed using affected-sib-pair approaches. When there is evidence that some covariates influence the phenotype, incorporation of this information is expected to increase the power of the analysis sinc...

Topics

Analysis of Variance
Computer Simulation
Genetic Linkage
Genotype
Humans
Models, Genetic
Models, Statistical
Multifactorial Inheritance
Nuclear Family
Phenotype
Quantitative Trait, Heritable

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