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Article

Incorporation of covariates in multipoint model-free linkage analysis of binary traits: how important are unaffecteds?

European journal of human genetics : EJHG - 1 Aug 2001

Alcaïs A, Abel L

Abstract excerpt

When the mode of inheritance is unknown, genetic linkage analysis of binary trait is commonly performed using affected-sib-pair approaches. When there is evidence that some covariates influence the phenotype, incorporation of this information is expected to increase the power of the analysis since it allows (1) a better specification of the phenotype and (2) to take into account unaffected subjects. Here, we show...

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PMID: 11528507
DOI: 10.1038/sj.ejhg.5200682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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