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Article

Maximum-Likelihood-Binomial method for genetic model-free linkage analysis of quantitative traits in sibships.

Genetic epidemiology - 1 Jan 1999

Alcaïs A, Abel L

Abstract excerpt

Sib-pair linkage studies are widely used to investigate the genetic factors implicated in complex quantitative traits. To analyze these data, we propose a Maximum-Likelihood-Binomial (MLB) approach, which considers the sibship as a whole and relies on the idea of binomial distributions of parental alleles among offsprings. The method is based on the introduction of a latent binary variable capturing the linkage...

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PMID: 10414555
DOI: 10.1002/(SICI)1098-2272(1999)17:2<102::AID-GEPI2>3.0.CO;2-6

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