Article
Genetic model-free linkage analysis using the maximum-likelihood-binomial method for categorical traits.
Genetic epidemiology - 1 Jan 1999
Alcaïs A, Philippi A, Abel L
Abstract excerpt
Within the simulated data of the 11th Genetic Analysis Workshop, we searched for the genes controlling the disease. We analyzed 200 families from Studies 2 and 3 presenting both mild and severe forms of disease. Linkage analysis was performed using the recently developed genetic model-free maximum-likelihood-binomial (MLB) method which overcomes the problem of multiple sibs by considering the sibship as a whole....
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