The actin-binding cleft: functional characterisation of myosin II with a strut mutation.

Abstract excerpt

The myosin cross-bridge has two essential properties: to undergo the "power stroke" and to bind and release from actin - both under control of ATP binding and hydrolysis. In the absence of ATP the cross-bridge binds to actin with high affinity: the binding of ATP causes rapid release of the cross-bridge from actin. The actin binding-site is split by a deep cleft that closes on strong binding to actin. The cleft...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Actins
• Share to Adenosine Triphosphate
• Share to Mutation