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Article

Function of the head-tail junction in the activity of myosin II.

Biochemical and biophysical research communications - 1 Nov 2013

Haraguchi Takeshi, Honda Kei, Wanikawa Yuichi, Shoji Nao, Yamamoto Keiichi, Ito Kohji

Abstract excerpt

All class II myosins have the conserved amino acid sequence Pro-Leu-Leu at their head-tail junctions. We systematically altered this sequence in smooth muscle heavy meromyosin (HMM) by site-directed mutagenesis and examined the effects of these mutations on actin-myosin interactions. Deletion of the proline and second leucine did not cause any noticeable change in either actin-activated ATPase activity or...

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Identifiers

PMID: 24041685
DOI: 10.1016/j.bbrc.2013.09.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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