Skeletal muscle myopathy mutations at the actin tropomyosin interface that cause gain- or loss-of-function.

Abstract excerpt

It is well known that the regulation of muscle contraction relies on the ability of tropomyosin to switch between different positions on the actin filament, but it is still not well understood which amino acids are directly involved in the different states of the interaction. Recently the structure of the actin-tropomyosin interface has been determined both in the absence and presence of myosin heads....

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