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Article

Switch I closure simultaneously promotes strong binding to actin and ADP in smooth muscle myosin.

The Journal of biological chemistry - 24 Jun 2011

Decarreau Justin A, James Nicholas G, Chrin Lynn R, Berger Christopher L

Abstract excerpt

The motor protein myosin uses energy derived from ATP hydrolysis to produce force and motion. Important conserved components (P-loop, switch I, and switch II) help propagate small conformational changes at the active site into large scale conformational changes in distal regions of the protein. Structural and biochemical studies have indicated that switch I may be directly responsible for the reciprocal opening...

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Identifiers

PMID: 21536675
DOI: 10.1074/jbc.M111.219014
PMCID: PMC3121376

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