Article

Mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin

2018-02-16

Abstract excerpt

<h4>Summary:</h4> Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity and ATPase activityof myosin have not provided a consistent mechanism to link mutations to muscle pathology. An alternative modelpositsthat mutations in myosin affect the stability ofa sequestered, super-...

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Literature Corpus work: 17c22b39-5987-5cb8-bf64-2e6e3903f7e3
DOI: 10.1101/266783

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