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Article

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.

Nature genetics - 1 Apr 1998

Yamasaki L, Bronson R, Williams B O, Dyson N J, Harlow E, Jacks T

Abstract excerpt

Mutation of the retinoblastoma tumour-suppressor gene (RB) leads to the deregulation of many proteins and transcription factors that interact with the retinoblastoma gene product (pRB), including members of the E2F transcription factor family. As pRB is known to repress E2F transcriptional activi...

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Source

Identifiers

PMID: 9537419
DOI: 10.1038/ng0498-360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9537419-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.PMID 9537419Read ↗

E2F4 loss suppresses tumorigenesis in Rb mutant mice.Semantic proximity Read ↗

E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.Semantic proximity Read ↗

E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.Semantic proximity Read ↗

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.Semantic proximity Read ↗

Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.Semantic proximity Read ↗

Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary GlandSemantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Retinoblastoma family proteins: insights gained through genetic manipulation of mice.Semantic proximity Read ↗

Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.Semantic proximity Read ↗

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent EpitheliaSemantic proximity Read ↗

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.Semantic proximity Read ↗

An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.Semantic proximity Read ↗

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