Article
Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation.
Oncogene - 6 Mar 2008
Julian L M, Palander O, Seifried L A, Foster J E G, Dick F A
Abstract excerpt
The retinoblastoma protein (pRB) has the dual capability to negatively regulate both E2F-induced cell cycle entry and E2F1-induced apoptosis. In this report, we characterize a unique pRB-E2F1 interaction. Using mutagenesis to disrupt E2F1 binding, we find that the ability of pRB to regulate E2F1-induced apoptosis is diminished when this interaction is lost. Strikingly, this mutant form of pRB retains the ability...
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