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Article

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.

Molecular and cellular biology - 1 Jun 2014

Cecchini Matthew J, Thwaites Michael J, Talluri Srikanth, MacDonald James I, Passos Daniel T, Chong Jean-Leon, Cantalupo Paul, Stafford Paul M, Sáenz-Robles M Teresa, Francis Sarah M, Pipas James M, Leone Gustavo, Welch Ian, Dick Frederick A

Abstract excerpt

The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report, we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of E2Fs. Mice that carry this mutation endogenously (Rb1(ΔG)) are defective for pRB-dependent repression of E2F target genes. Except for an accelerated entry into S...

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Identifiers

PMID: 24662053
DOI: 10.1128/MCB.01589-13
PMCID: PMC4019062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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