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Article

Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse.

Genesis (New York, N.Y. : 2000) - 1 Feb 2010

Xiao Hai, Zhang Xiaojing, Goodrich David W

Abstract excerpt

Loss of Rb1 tumor suppressor gene function is involved in the genesis of most human cancers. Novel therapies targeting Rb1 have been slow to develop because of our incomplete understanding of its molecular mechanisms of action. Rb1 protein (pRb) binds a host of cellular genes and proteins, and these molecular interactions mediate its various functions. Given the potential complexity of these molecular...

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Identifiers

PMID: 20027616
DOI: 10.1002/dvg.20589
PMCID: PMC2819610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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