Article
Nuclear factor kappaB is required for peptide antigen-induced differentiation of a CD4+CD8+ thymocyte line.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998
Ochoa-Garay J, Kaye J, Coligan J E
Abstract excerpt
NF-kappaB transcription factors are known to regulate the expression of a number of genes involved in T cell activation and function. Some evidence has suggested that they also play a role in T cell development. However, the role of NF-kappaB in Ag-induced thymocyte differentiation has not been d...
Topics
- Animals
- Antigens
- Apoptosis
- Base Sequence
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cell Line
- Cell Nucleus
- Columbidae
- Cytochrome c Group
- DNA-Binding Proteins
- Humans
- I-kappa B Proteins
- Mice
- Mutation
- NF-KappaB Inhibitor alpha
- NF-kappa B