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Article

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

Science (New York, N.Y.) - 21 Jan 2005

Hwang Eun Sook, Szabo Susanne J, Schwartzberg Pamela L, Glimcher Laurie H

Abstract excerpt

Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through...

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Identifiers

PMID: 15662016
DOI: 10.1126/science.1103336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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