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Article

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2001

Michie A M, Soh J W, Hawley R G, Weinstein I B, Zuniga-Pflucker J C

Abstract excerpt

Pre-T cell receptor (preTCR)-derived signals mediate the transition of thymocytes from the CD4(-) CD8(-) double-negative (DN) to CD4(+) CD8(+) double-positive stage of T lymphocyte development. This progression, termed beta-selection, is limited to thymocytes that have generated a functional TCR-beta chain able to associate with pTalpha to form the preTCR complex. Formation of the preTCR complex not only induces...

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Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

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Share to Phosphatidylinositol Diacylglycerol-Lyase

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Source

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Identifiers

PMID: 11149941
DOI: 10.1073/pnas.98.2.609
PMCID: PMC14635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.PMID 11149941Read ↗

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