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Article

Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors.

Nature reviews. Immunology - 1 Nov 2012

Oestreich Kenneth J, Weinmann Amy S

Abstract excerpt

There is an emerging body of research demonstrating that the co-expression of key lineage-specifying transcription factors, commonly referred to as 'master regulators', affects the functional capabilities and flexibility of CD4(+) T cell subsets. Here, we discuss how the natural co-expression of these lineage-specifying transcription factors has challenged the concept that the expression of a single 'master...

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Share to Proto-Oncogene Proteins c-bcl-6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GATA3 Transcription Factor

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Source

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Identifiers

PMID: 23059426
DOI: 10.1038/nri3321
PMCID: PMC3584691

Genes

FOXP3
GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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