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Article

Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation.

Immunity - 1 Aug 1994

Poirier G, Lo D, Reilly C R, Kaye J

Abstract excerpt

During their intrathymic migration, immature CD4+ CD8+ thymocytes that express a TCR able to recognize the expressed MHC molecules are positively selected, i.e., complete their differentiation program and become mature T cells. Using the immature CD4+CD8+ T cell line DPK, which can be induced to differentiate in culture, we show here that a subset of isolated thymic epithelial cells, but not peripheral...

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PMID: 7882169
DOI: 10.1016/1074-7613(94)90069-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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