Sensitive detection of p53 gene mutations in esophageal endoscopic biopsy specimens by cell sorting combined with polymerase chain reaction single-strand conformation polymorphism analysis.

doi:10.1111/j.1349-7006.1992.tb02754.x

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Article

Sensitive detection of p53 gene mutations in esophageal endoscopic biopsy specimens by cell sorting combined with polymerase chain reaction single-strand conformation polymorphism analysis.

Japanese journal of cancer research : Gann - 1 Dec 1992

Maesawa C, Tamura G, Suzuki Y, Ishida K, Saito K, Satodate R

Abstract excerpt

For the rapid and sensitive detection of p53 gene mutations in esophageal endoscopic biopsy specimens, we combined cell sorting with the polymerase chain reaction and single-strand conformation polymorphism (PCR-SSCP) analysis. Mutations in exons 5-8 of the p53 gene were investigated by PCR-SSCP...

Topics

Aged
Aneuploidy
Base Sequence
Biopsy
Diploidy
Esophageal Neoplasms
Esophagus
Exons
Female
Flow Cytometry
Genes, p53
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 1483940
DOI: 10.1111/j.1349-7006.1992.tb02754.x
PMCID: PMC5918734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1483940-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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