Article
Aspects of the design and analysis of high-dimensional SNP studies for disease risk estimation.
Biostatistics (Oxford, England) - 1 Jul 2006
Prentice Ross L, Qi Lihong
Abstract excerpt
The state of readiness for high-dimensional single nucleotide polymorphism (SNP) epidemiologic association studies is described, as background for a discussion of statistical aspects of case-control study design and analysis. Specifically, the important role that multistage designs can play in the elimination of false-positive associations and in the control of study costs will be noted. Also, the trade-offs...
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