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Article

A comparative study of cytoplasmic granules imaged by the real-time microscope, Nile Red and Filipin in fibroblasts from patients with lipid storage diseases.

Journal of inherited metabolic disease - 1 Jan 2005

Pham N-A, Gal M R, Bagshaw R D, Mohr A J, Chue B, Richardson T, Callahan J W

Abstract excerpt

Cytoplasmic granules in fibroblasts, visualized without stains, or labelled with Nile red, Filipin, or anti-LAMP-1 (lysosome-associated membrane protein 1), were imaged using the real-time microscope (RTM). New advances in light microscope technology were applied to detect cytoplasmic granules (RTM-visible granules) and characterize them by imaging contrast, size, shape, cellular distribution, composition, motion...

Topics

Antifungal Agents
Cholesterol
Cytoplasm
Cytoplasmic Granules
Fibroblasts
Filipin
G(M1) Ganglioside
Humans
Image Processing, Computer-Assisted
Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipidoses

Lipids

Lysosomal Membrane Proteins

Microscopy

Microscopy, Fluorescence

Oxazines

Phenotype

Wolman Disease

Source

Identifiers

PMID: 16435192
DOI: 10.1007/s10545-005-0117-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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