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Article

Impaired mitochondrial morphological plasticity and failure of mitophagy associated with the G11778A mutation of LHON.

Biochemical and biophysical research communications - 20 Aug 2024

Pasqualotto Bryce A, Nelson Alexa, Deheshi Samineh, Sheldon Claire A, Vogl A Wayne, Rintoul Gordon L

Abstract excerpt

Mitochondrial dynamics were examined in human dermal fibroblasts biopsied from a confirmed Leber's Hereditary Optic Neuropathy (LHON) patient with a homoplasmic G11778A mutation of the mitochondrial genome. Expression of the G11778A mutation did not impart any discernible difference in mitochondrial network morphology using widefield fluorescence microscopy. However, at the ultrastructural level, cells expressing...

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Identifiers

PMID: 38768545
DOI: 10.1016/j.bbrc.2024.150119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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