Article

Live-cell Raman imaging of Pompe disease reveals extensive sarcoplasmic accumulations of precipitated glycogen

2025-08-12

Abstract excerpt

<title>Abstract</title> <p>Pompe disease is a genetic myopathy characterised by inadequate levels of lysosomal acid α-1,4-glucosidase (GAA). This deficiency leads to the abnormal accumulation of glycogen in lysosomes, primarily affecting skeletal muscle cells. As research and treatment options progress, accurate methods for evaluating glycogen storage are crucial. We employed Raman spectroscopy to analyse glycoge...

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Literature Corpus work: 7dcc1ae9-8645-5c0f-8de1-0dc74e259791
DOI: 10.21203/rs.3.rs-6915782/v1

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