Article
The same genomic region is disrupted in two transgene-induced limb deformity alleles.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1992
Vogt T F, Jackson-Grusby L, Wynshaw-Boris A J, Chan D C, Leder P
Abstract excerpt
Mutations of the mouse limb deformity locus, ld, map to Chromosome (Chr) 2 and result in defects in the morphogenesis and patterning of the limb and kidney. Complementation studies have defined the existence of five recessive ld alleles. Remarkably, two of these, ldTgHd and ldTgBri, are transgene-induced mutations. Recovery of the first transgene insertional allele, ldTgHd, facilitated the molecular cloning of a...
Topics
- Alleles
- Animals
- Chromosome Deletion
- Chromosome Mapping
- Extremities
- Genes
- Genetic Complementation Test
- Mice
- Mice, Transgenic
- Recombination, Genetic