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Article

Genetic evidence that formins function within the nucleus.

The Journal of biological chemistry - 20 Sept 1996

Chan D C, Leder P

Abstract excerpt

The murine limb deformity (ld) locus encodes a set of proteins, termed formins, that are required for embryonic limb and kidney development. Previous studies had indicated that these proteins are located in the nucleus and cytoplasm and have biochemical properties consistent with an action within the nucleus. To test the notion that nuclear localization is crucial for formin function, we carried out molecular and...

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Identifiers

PMID: 8798555
DOI: 10.1074/jbc.271.38.23472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Genetic evidence that formins function within the nucleus.PMID 8798555Read ↗

Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus.Semantic proximity Read ↗

The same genomic region is disrupted in two transgene-induced limb deformity alleles.Semantic proximity Read ↗

Cajal bodies and histone locus bodies in Drosophila and Xenopus.Semantic proximity Read ↗

Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Semantic proximity Read ↗

A point mutation in human coilin prevents Cajal body formation.Semantic proximity Read ↗

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene.Semantic proximity Read ↗

Control of Cajal body number is mediated by the coilin C-terminus.Semantic proximity Read ↗

Nuclear localization of the dystrophin-associated protein α-dystrobrevin through importin α2/β1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity.Semantic proximity Read ↗

The role of a single formin isoform in the limb and renal phenotypes of limb deformity.Semantic proximity Read ↗

A predominantly nuclear protein affecting cytoplasmic localization of beta-actin mRNA in fibroblasts and neurons.Semantic proximity Read ↗

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