An inherited limb deformity created by insertional mutagenesis in a transgenic mouse.

doi:10.1038/318036a0

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Article

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse.

Nature - 1 Jan 2000

Woychik R P, Stewart T A, Davis L G, D'Eustachio P, Leder P

Abstract excerpt

We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominan...

Topics

Animals
Chromosome Mapping
Cloning, Molecular
Extremities
Genes, Recessive
Genetic Complementation Test
Mammary Tumor Virus, Mouse
Mice
Mutation
Pedigree
Phenotype
Proto-Oncogenes
Transformation, Genetic

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