Article
Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.
Genes & development - 1 Jul 2004
Zuniga Aimée, Michos Odyssé, Spitz François, Haramis Anna-Pavlina G, Panman Lia, Galli Antonella, Vintersten Kristina, Klasen Christian, Mansfield William, Kuc Sylwia, Duboule Denis, Dono Rosanna, Zeller Rolf
Abstract excerpt
The mouse limb deformity (ld) mutations cause limb malformations by disrupting epithelial-mesenchymal signaling between the polarizing region and the apical ectodermal ridge. Formin was proposed as the relevant gene because three of the five ld alleles disrupt its C-terminal domain. In contrast, our studies establish that the two other ld alleles directly disrupt the neighboring Gremlin gene, corroborating the...
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