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Article

Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1993

Vogt T F, Jackson-Grusby L, Rush J, Leder P

Abstract excerpt

Mutations at the mouse limb deformity (ld) locus result in defects of growth and patterning of the limb and kidney during embryonic development. The gene responsible for this phenotype is large and complex, with the capacity to generate a number of alternatively spliced messenger RNA transcripts encoding nuclear protein isoforms called "formins." We have made polyclonal antibodies to specific formin peptides and...

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Identifiers

PMID: 8516300
DOI: 10.1073/pnas.90.12.5554
PMCID: PMC46759

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Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus.PMID 8516300Read ↗

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene.Semantic proximity Read ↗

Genetic evidence that formins function within the nucleus.Semantic proximity Read ↗

Disruption of formin-encoding transcripts in two mutant limb deformity alleles.Semantic proximity Read ↗

HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophySemantic proximity Read ↗

The same genomic region is disrupted in two transgene-induced limb deformity alleles.Semantic proximity Read ↗

A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs.Semantic proximity Read ↗

The role of a single formin isoform in the limb and renal phenotypes of limb deformity.Semantic proximity Read ↗

The impact of alternative splicing in vivo: mouse models show the way.Semantic proximity Read ↗

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Mouse fibroblast activation protein: Molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancersSemantic proximity Read ↗

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