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Article

Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice.

Human molecular genetics - 1 Oct 2017

Kumamoto Soichiro, Takahashi Nozomi, Nomura Kayo, Fujiwara Makoto, Kijioka Megumi, Uno Yoshinobu, Matsuda Yoichi, Sotomaru Yusuke, Kono Tomohiro

Abstract excerpt

The Dlk1-Dio3 imprinted domain functions in embryonic development but the roles of noncoding RNAs expressed from this domain remain unclear. We addressed this question by generating transgenic (TG) mice harbouring a BAC carrying IG-DMR (intergenic-differentially methylated region), Gtl2-DMR, Gtl2, Rtl1/Rtl1as, and part of Rian. High postnatal lethality (>85%) of the BAC-TG pups was observed in the maternally...

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Identifiers

PMID: 28934383
DOI: 10.1093/hmg/ddx223
PMCID: PMC5886287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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