Article
'Formins': proteins deduced from the alternative transcripts of the limb deformity gene.
Nature - 30 Aug 1990
Woychik R P, Maas R L, Zeller R, Vogt T F, Leder P
Abstract excerpt
Vertebrate limb formation is an evolutionarily conserved process programmed by an array of morphogenetic genes. As a result of transgene insertion, we previously identified a mutation at the mouse limb deformity (ld) locus that disrupts embryonic pattern formation, resulting in a reduction and fusion of the distal bones and digits of all limbs as well as variable incidence of renal aplasia. We have now...
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