The role of a single formin isoform in the limb and renal phenotypes of limb deformity.

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Article

The role of a single formin isoform in the limb and renal phenotypes of limb deformity.

Molecular medicine (Cambridge, Mass.) - 1 Jun 1997

Wynshaw-Boris A, Ryan G, Deng C X, Chan D C, Jackson-Grusby L, Larson D, Dunmore J H, Leder P

Abstract excerpt

BACKGROUND: Mutations of the murine limb deformity (ld) locus are responsible for a pleiotropic phenotype of completely penetrant limb malformations and incompletely penetrant renal agenesis and/or dysgenesis. The ld locus encodes a complex family of mRNA and protein isoforms. MATERIALS AND METHO...

Topics

Abnormalities, Multiple
Alleles
Alternative Splicing
Animals
Crosses, Genetic
DNA, Complementary
Fetal Proteins
Formins
Gene Targeting
In Situ Hybridization
Kidney
Limb Deformities, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Mutant Strains

Microfilament Proteins

Mutagenesis

Nuclear Proteins

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 9234242
PMCID: PMC2230207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9234242-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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