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Article

The role of a single formin isoform in the limb and renal phenotypes of limb deformity.

Molecular medicine (Cambridge, Mass.) - 1 Jun 1997

Wynshaw-Boris A, Ryan G, Deng C X, Chan D C, Jackson-Grusby L, Larson D, Dunmore J H, Leder P

Abstract excerpt

BACKGROUND: Mutations of the murine limb deformity (ld) locus are responsible for a pleiotropic phenotype of completely penetrant limb malformations and incompletely penetrant renal agenesis and/or dysgenesis. The ld locus encodes a complex family of mRNA and protein isoforms. MATERIALS AND METHODS: To examine the role of one of the more prominent of these isoforms, isoform IV, we specifically eliminated it by...

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Identifiers

PMID: 9234242
PMCID: PMC2230207

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The role of a single formin isoform in the limb and renal phenotypes of limb deformity.PMID 9234242Read ↗

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