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Article

Disruption of formin-encoding transcripts in two mutant limb deformity alleles.

Nature - 30 Aug 1990

Mass R L, Zeller R, Woychik R P, Vogt T F, Leder P

Abstract excerpt

The recent identification of a gene residing at the mouse limb deformity (ld) locus permits us to test the hypothesis that disruption of this gene is responsible for an inherited anomaly affecting embryonic pattern formation. The gene gives rise to alternatively processed messenger RNAs that can be translated as a family of related protein products, termed the formins. We have now analysed transcripts from this...

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PMID: 2392151
DOI: 10.1038/346853a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Disruption of formin-encoding transcripts in two mutant limb deformity alleles.PMID 2392151Read ↗

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene.Semantic proximity Read ↗

A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs.Semantic proximity Read ↗

The same genomic region is disrupted in two transgene-induced limb deformity alleles.Semantic proximity Read ↗

The role of a single formin isoform in the limb and renal phenotypes of limb deformity.Semantic proximity Read ↗

Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus.Semantic proximity Read ↗

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.Semantic proximity Read ↗

Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation.Semantic proximity Read ↗

Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.Semantic proximity Read ↗

The mouse formin (Fmn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis.Semantic proximity Read ↗

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse.Semantic proximity Read ↗

Polydactyly in the Strong's luxoid mouse is suppressed by limb deformity alleles.Semantic proximity Read ↗

Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.Semantic proximity Read ↗

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