Article
Disruption of formin-encoding transcripts in two mutant limb deformity alleles.
Nature - 30 Aug 1990
Mass R L, Zeller R, Woychik R P, Vogt T F, Leder P
Abstract excerpt
The recent identification of a gene residing at the mouse limb deformity (ld) locus permits us to test the hypothesis that disruption of this gene is responsible for an inherited anomaly affecting embryonic pattern formation. The gene gives rise to alternatively processed messenger RNAs that can...
Topics
- Alleles
- Animals
- DNA Probes
- Exons
- Extremities
- Gene Expression
- Limb Deformities, Congenital
- Mice
- Mice, Transgenic
- Morphogenesis
- Mutation
- Nuclear Proteins
- Nucleic Acid Hybridization
- Phenotype
- RNA Splicing
- RNA, Messenger
- Ribonucleases
- Transcription, Genetic