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Article

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein.

Molecular and cellular biology - 1 Aug 2009

Duxin Julien P, Dao Benjamin, Martinsson Peter, Rajala Nina, Guittat Lionel, Campbell Judith L, Spelbrink Johannes N, Stewart Sheila A

Abstract excerpt

Dna2 is a highly conserved helicase/nuclease that in yeast participates in Okazaki fragment processing, DNA repair, and telomere maintenance. Here, we investigated the biological function of human Dna2 (hDna2). Immunofluorescence and biochemical fractionation studies demonstrated that hDna2 was present in both the nucleus and the mitochondria. Analysis of mitochondrial hDna2 revealed that it colocalized with a...

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Source

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Identifiers

PMID: 19487465
DOI: 10.1128/MCB.01834-08
PMCID: PMC2715806

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Source receipt: pubmed, retrieved 7 Sept 2026.

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