Article
Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.
Journal of hypertension - 1 Jun 2006
Semplicini Andrea, Lenzini Livia, Sartori Michelangelo, Papparella Italia, Calò Lorenzo A, Pagnin Elisa, Strapazzon Giacomo, Benna Clara, Costa Rodolfo, Avogaro Angelo, Ceolotto Giulio, Pessina Achille C
Abstract excerpt
CONTEXT: RGS2 (regulators of G-protein signaling) is a negative regulator of Galphaq protein signaling, which mediates the action of several vasoconstrictors. RGS2-deficient mouse line exhibits a hypertensive phenotype and a prolonged response to vasoconstrictors. OBJECTIVE: To compare RGS2 expression in peripheral blood mononuclear cells (PBMs) and cultured fibroblasts from normotensive subjects and hypertensive...
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