Article
Checkpoint independence of most DNA replication origins in fission yeast.
BMC molecular biology - 19 Dec 2007
Mickle Katie L, Ramanathan Sunita, Rosebrock Adam, Oliva Anna, Chaudari Amna, Yompakdee Chulee, Scott Donna, Leatherwood Janet, Huberman Joel A
Abstract excerpt
BACKGROUND: In budding yeast, the replication checkpoint slows progress through S phase by inhibiting replication origin firing. In mammals, the replication checkpoint inhibits both origin firing and replication fork movement. To find out which strategy is employed in the fission yeast, Schizosaccharomyces pombe, we used microarrays to investigate the use of origins by wild-type and checkpoint-mutant strains in...
Topics
- Cell Cycle Proteins
- Checkpoint Kinase 2
- Chromosomes
- DNA Replication
- DNA, Fungal
- Hydroxyurea
- Microarray Analysis
- Mutation
- Nucleic Acid Synthesis Inhibitors
- Protein Kinases