Article

VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism

2023-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Menopause adversely impacts systemic energy metabolism and increases the risk of metabolic disease(s) including hepatic steatosis, but the mechanisms are largely unknown. Dosing female mice with vinyl cyclohexene dioxide (VCD) selectively causes follicular atresia in ovaries, leading to a murine menopause-like phenotype. In this study, we treated female C57BL6/J mice with VCD (160mg/kg i.p. for...

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Literature Corpus work: a25f0dc2-6435-50ae-ab75-7d6ed31f13ab
DOI: 10.1101/2023.12.14.571644

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