Article
Systematic characterization of the ovarian landscape across mouse menopause models
2025-06-15
Abstract excerpt
Menopause affects not only fertility but also systemic health. Yet mechanisms underlying this coupling are still poorly understood, partly due to the absence of robust, age-relevant preclinical models with comprehensive molecular and phenotypic characterization. To address this, we systematically compared three candidate mouse models of menopause: (1) intact aging, (2) chemical ovarian follicle depletion using 4-v...
Topics
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- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- Genetic and phenotypic traits in livestock
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Single-cell and spatial transcriptomics
- Sperm and Testicular Function
Identifiers and source
- Literature Corpus work
- 4622be3d-2299-520c-87bf-cb31654ab48c
- DOI
- 10.1101/2025.06.10.658920