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Article

A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.

The American journal of pathology - 1 Apr 2007

Yang Wan-Lin, Cai Kathy Qi, Smedberg Jennifer L, Smith Elizabeth R, Klein-Szanto Andres, Hamilton Thomas C, Xu Xiang-Xi

Abstract excerpt

Menopausal ovaries undergo morphological changes, known as ovarian aging, which are implicated in the high incidence of ovarian cancer occurring during the perimenopausal and immediate postmenopausal periods. The germ cell-deficient Wv mice recapitulate these postmenopausal alterations in ovarian morphology and develop tubular adenomas. We demonstrate that a reduction of cyclooxygenase 2 gene dosage rescued the...

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Identifiers

PMID: 17392171
DOI: 10.2353/ajpath.2007.060769
PMCID: PMC1829465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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