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Article

An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene.

Endocrinology - 1 Jul 2000

Britt K L, Drummond A E, Cox V A, Dyson M, Wreford N G, Jones M E, Simpson E R, Findlay J K

Abstract excerpt

With the development of a mouse model of estrogen insufficiency due to targeted disruption of the aromatase gene [the aromatase knockout (ArKO) mouse], a new opportunity exists to examine the role of estrogen in ovarian follicular development. Ovaries and serum were collected from wild-type, heterozygous, and ArKO mice at 10-12 and 21-23 weeks and 1 yr of age. The ovaries were assessed histologically and...

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Source

Identifiers

PMID: 10875266
DOI: 10.1210/endo.141.7.7578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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