Article
The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization.
Blood - 1 Sept 2002
Tao Wen, Filippi Marie-Dominique, Bailey Jeffrey R, Atkinson Simon J, Connors Bret, Evan Andrew, Williams David A
Abstract excerpt
Rac GTPases regulate a wide variety of cellular processes including actin cytoskeleton organization, gene expression, cell-cycle progression, and apoptosis. Here we report that the TRQQKRP motif of Rac2 located near the C-terminus, a region of sequence disparity among Rac proteins, is essential for complementation of Rac2 function in Rac2-deficient cells. Deletion of this sequence can also intragenically suppress...
Topics
- 3T3 Cells
- Amino Acid Motifs
- Animals
- Cell Differentiation
- Cell Division
- Cell Movement
- Mice
- Mice, Inbred C57BL
- Mutation
- Neutrophils
- rac GTP-Binding Proteins
- RAC2 GTP-Binding Protein