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Article

Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells.

Human mutation - 1 Aug 2011

Mendez-Bermudez Aaron, Royle Nicola J

Abstract excerpt

DNA mismatch repair (MMR) is essential for genome stability and inheritance of a mutated MMR gene, most frequently MSH2 or MLH1, results in cancer predisposition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC). Tumors that arise through MMR deficiency show instability at simple tandem repeat loci (STRs) throughout the genome, known as microsatellite instability (MSI). The STR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21538690
DOI: 10.1002/humu.21522

Genes

MSH2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells.PMID 21538690Read ↗

DNA mismatch repair deficiency and telomere dynamicsSemantic proximity Read ↗

MSH2 deficiency abolishes the anticancer and pro‐aging activity of short telomeresSemantic proximity Read ↗

Analysis of telomere dynamics in peripheral blood cells from patients with Lynch syndrome.Semantic proximity Read ↗

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.Semantic proximity Read ↗

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.Semantic proximity Read ↗

Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level.Semantic proximity Read ↗

DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage responseSemantic proximity Read ↗

Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivoSemantic proximity Read ↗

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Semantic proximity Read ↗

Deficiency in DNA mismatch repair of methylation damage is a major mutational process in cancerSemantic proximity Read ↗

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function.Semantic proximity Read ↗

Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of ageSemantic proximity Read ↗

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