Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis

15 Jan 2004

Abstract excerpt

Mutations in the human DNA mismatch repair gene MSH2 are associated with hereditary nonpolyposis colorectal cancer as well as a significant proportion of sporadic colorectal cancer. The inactivation of MSH2 results in the accumulation of somatic mutations in the genome of tumor cells and resistance to the genotoxic effects of a variety of chemotherapeutic agents. Here we show that the DNA repair and DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14744764
DOI: 10.1158/0008-5472.can-03-2957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Msh2 Point Mutation Uncouples DNA Mismatch Repair and ApoptosisPMID 14744764Read ↗

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility.Semantic proximity Read ↗

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice.Semantic proximity Read ↗

Association of a novel point mutation in MSH2 gene with familial multiple primary cancers.Semantic proximity Read ↗

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Semantic proximity Read ↗

Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch RecombinationSemantic proximity Read ↗

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.Semantic proximity Read ↗

MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability.Semantic proximity Read ↗

Pancreatic cancer and a novel MSH2 germline alteration.Semantic proximity Read ↗

MSH2 deficient mice are viable and susceptible to lymphoid tumours.Semantic proximity Read ↗

Proteasome inhibition rescues clinically significant unstable variants of the mismatch repair protein Msh2Semantic proximity Read ↗

Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.Semantic proximity Read ↗

The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.