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Article

Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation.

Haematologica - 1 Oct 2006

Granell Miquel, Urbano-Ispizua Alvaro, Aróstegui Juan Ignacio, Fernández-Avilés Francesc, Martínez Carmen, Rovira Montserrat, Rius Josefa, Plaza Susana, Gaya Anna, Navarro Alfons, Talarn Carme, Carreras Enric, Monzó Mariano, Montserrat Emili, Yagüe Jordi

Abstract excerpt

BACKGROUND AND OBJECTIVES: Three single nucleotide polymorphisms (SNP) in the NOD2/CARD15 gene have been associated with the incidence and the severity of acute graft-versus-host disease (GVHD) following allogeneic stem cell transplantation (SCT). We hypothesized that the clinical effect of SNP in NOD2/CARD15 might be different in patients submitted to T-cell-depleted allogeneic SCT, in which donor T cells, the...

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Source

Identifiers

PMID: 17018387

Genes

NOD2
SCT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation.PMID 17018387Read ↗

Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.Semantic proximity Read ↗

The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation.Semantic proximity Read ↗

NOD2/CARD15 variants are not a risk factor for clinical outcome after nonmyeloablative allogeneic stem cell transplantation.Semantic proximity Read ↗

Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.Semantic proximity Read ↗

Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination.Semantic proximity Read ↗

No impact of NOD2/CARD15 on outcome after SCT.Semantic proximity Read ↗

Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation.Semantic proximity Read ↗

Polymorphisms within epithelial receptors: NOD2/CARD15.Semantic proximity Read ↗

NOD2 polymorphisms predict severe acute graft-versus-host and treatment-related mortality in T-cell-depleted haematopoietic stem cell transplantation.Semantic proximity Read ↗

Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.Semantic proximity Read ↗

Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients.Semantic proximity Read ↗

Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation.Semantic proximity Read ↗

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