Article
Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2007
Mayor Neema P, Shaw Bronwen E, Hughes Derralynn A, Maldonado-Torres Hazael, Madrigal J Alejandro, Keshav Satish, Marsh Steven G E
Abstract excerpt
PURPOSE: Hematopoietic stem cell transplantation (HSCT) is an important option in the management of acute leukemia, but the risk of disease relapse and death remains appreciable. Recent studies have suggested that nucleotide-binding oligomerization domain 2 (NOD2)/caspase recruitment domain 15 (CARD15) gene single nucleotide polymorphisms (SNPs), implicated in innate immunity and Crohn's disease, may also affect...
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