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Article

NOD2/CARD15 variants are not a risk factor for clinical outcome after nonmyeloablative allogeneic stem cell transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Aug 2011

van der Straaten Hanneke M, Paquay Martine M, Tilanus Marcel G J, van Geloven Nan, Verdonck Leo F, Huisman Cynthia

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the innate immunity receptor NOD2/CARD15 have been demonstrated to modulate the outcome of allogeneic hematopoietic stem cell transplantation (SCT). The effect of NOD2/CARD15 polymorphism is reported to be associated with type of donor (sibling or matched unrelated donor) as well as type of conditioning regimen. We reviewed NOD2/CARD15 SNPs in all donor/recipient pairs of...

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Source

Identifiers

PMID: 21215810
DOI: 10.1016/j.bbmt.2010.12.709

Genes

NOD2
SCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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NOD2/CARD15 variants are not a risk factor for clinical outcome after nonmyeloablative allogeneic stem cell transplantation.PMID 21215810Read ↗

The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation.Semantic proximity Read ↗

Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation.Semantic proximity Read ↗

Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.Semantic proximity Read ↗

No impact of NOD2/CARD15 on outcome after SCT.Semantic proximity Read ↗

Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.Semantic proximity Read ↗

Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination.Semantic proximity Read ↗

Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.Semantic proximity Read ↗

Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation.Semantic proximity Read ↗

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NOD2/CARD15 gene mutation is not associated with susceptibility to Wegener's granulomatosis.Semantic proximity Read ↗

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