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Article

SUMO operates from a unique long tandem repeat to keep innate immunity in check

19 Jul 2025

Abstract excerpt

The SUMO pathway mainly functions to repress innate immunity in myeloid cells. Inactivating sumoylation triggers a strong, noncanonical, type I interferon (IFN1) response, amplified and coupled with inflammation upon stimulation. These findings transposed to pre-clinical models with the demonstration that sumoylation inhibitors activate antitumor immunity in an IFN1-dependent manner. Yet, how sumoylation...

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PMID: 40744492
DOI: 10.1093/nar/gkaf750

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