Article
SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.
PloS one - 1 Jan 2012
Wang Yaju, Rao Vinay Kumar, Kok Wai Kay, Roy Dijendra Nath, Sethi Sumita, Ling Belinda Mei Tze, Lee Martin Beng Huat, Taneja Reshma
Abstract excerpt
Stra13, a basic helix-loop-helix (bHLH) transcription factor is involved in myriad biological functions including cellular growth arrest, differentiation and senescence. However, the mechanisms by which its transcriptional activity and function are regulated remain unclear. In this study, we provide evidence that post-translational modification of Stra13 by Small Ubiquitin-like Modifier (SUMO) dramatically...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- COS Cells
- Cell Cycle
- Cell Survival
- Chlorocebus aethiops
- Cyclin D1
- DNA-Binding Proteins
- Gene Expression Regulation
- HEK293 Cells
- Homeodomain Proteins
- Humans
- Mice