Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.

PloS one - 1 Jan 2012

Wang Yaju, Rao Vinay Kumar, Kok Wai Kay, Roy Dijendra Nath, Sethi Sumita, Ling Belinda Mei Tze, Lee Martin Beng Huat, Taneja Reshma

Abstract excerpt

Stra13, a basic helix-loop-helix (bHLH) transcription factor is involved in myriad biological functions including cellular growth arrest, differentiation and senescence. However, the mechanisms by which its transcriptional activity and function are regulated remain unclear. In this study, we provide evidence that post-translational modification of Stra13 by Small Ubiquitin-like Modifier (SUMO) dramatically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to COS Cells

Share to Cyclin D1

Share to Molecular Chaperones

Share to NIH 3T3 Cells

Share to Protein Processing, Post-Translational

Share to SUMO-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22905217
DOI: 10.1371/journal.pone.0043137
PMCID: PMC3419196

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.PMID 22905217Read ↗

Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms.Semantic proximity Read ↗

Sumoylation: a regulatory protein modification in health and disease.Semantic proximity Read ↗

The post-translational modification, SUMOylation, and cancer (Review)Semantic proximity Read ↗

RNF4—A Paradigm for SUMOylation‐Mediated UbiquitinationSemantic proximity Read ↗

Smurfs in Protein Homeostasis, Signaling, and CancerSemantic proximity Read ↗

Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.Semantic proximity Read ↗

Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation.Semantic proximity Read ↗

Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.Semantic proximity Read ↗

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.Semantic proximity Read ↗

RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence.Semantic proximity Read ↗

The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and TherapySemantic proximity Read ↗

An E3-like factor that promotes SUMO conjugation to the yeast septins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.