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Article

SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1).

The Journal of biological chemistry - 10 Sept 2004

Chen Wei-Yi, Lee Wen-Chih, Hsu Nai-Chi, Huang Fu, Chung Bon-Chu

Abstract excerpt

Steroidogenic factor 1 (SF-1 or NR5A1), is a Ftz-F1 member of the nuclear receptor superfamily that plays essential roles in endocrine development, steroidogenesis, and gonad differentiation. We investigated modifications that control SF-1 function and found that SF-1 could be conjugated by SUMO-1 both in vitro and in vivo. SF-1 was modified predominantly at Lys(194) and much less at Lys(119) when free SUMO-1 was...

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PMID: 15192092
DOI: 10.1074/jbc.M405006200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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