Article
Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.
Molecular cell - 1 May 2003
Lin Xia, Sun Baohua, Liang Min, Liang Yao-Yun, Gast Andreas, Hildebrand Jeffrey, Brunicardi F Charles, Melchior Frauke, Feng Xin-Hua
Abstract excerpt
The transcription corepressor CtBP is often recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor. In this study, we demonstrate that CtBP1 was SUMOylated and that its SUMOylation profoundly affected its subcellular localization. SUMOylation occurred at a single Lys residue, Lys428, of CtBP1. CtBP2, a close homolog of CtBP1, lacked the SUMOylation site and was...
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